Mitigation of Airborne PRRSV Transmission with UV Light Treatment: Proof-of-Concept

Proper treatment of infectious air could potentially mitigate the spread airborne viruses such as porcine reproductive and respiratory syndrome virus (PRRSV). The objective this research is to test effectiveness ultraviolet (UV) in inactivating aerosolized PRRSV, specifically, four UV lamps, UV-A (365 nm, both fluorescent LED-based), “excimer” UV-C (222 nm), germicidal (254 were tested. two lamps effectively irradiated fast-moving PRRSV aerosols with short times (<2 s). One-stage two-stage inactivation models estimated doses needed for target percentage (%) reductions on titer. nm) dose 3-log (99.9%) reduction was 19.43 2.44 mJ/cm2, respectively, based one-stage models. a 2.81 1.04 models, respectively. However, cost 222 nm excimer still economically prohibitive scaling-up trials. not reduce titers tested up 4.11 mJ/cm2. Pilot-scale or farm-scale testing simulating barn ventilation rates are recommended its reasonable costs comparable HEPA filtration.